Topical Rapamycin Targets Vascular Tumors via mTOR Pathway
A 2013 study published in Laboratory Investigation investigates the role of the mTOR signaling pathway—specifically the activation of p70 S6‑kinase—in both benign (infantile hemangioma) and malignant (angiosarcoma) vascular tumors. The researchers found that these tumors exhibit elevated levels of activated S6K and ribosomal protein S6. By using genetic knockdown, they demonstrated that reducing S6K levels […]